Multipotent Progenitor Identity
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes TCF7L2 (Wnt effector TF), BCL11A (lymphoid/HSC TF), MN1 (myeloid progenitor TF), BTG2 (anti-proliferative differentiation brake), DUSP6 (MAPK/ERK negative feedback), and DOCK1 (Rac GEF activator) collectively define a multipotent progenitor transcriptional identity module. SUN2 (nuclear lamina) and SEPTIN9 (cytoskeletal) support progenitor cell organization. BCL11A is a master regulator of HSC quiescence and lymphoid commitment; MN1 marks myeloid progenitors; TCF7L2 mediates Wnt-driven HSC self-renewal. The module captures a progenitor state balanced between self-renewal and commitment.
Genes
BCL11A, BTG2, DOCK1, DUSP6, MN1, NLRP1, PTPRE, SEPTIN9, STARD9, SUN2, TCF7L2
Most correlated modules
- HOX HSC Program · correlation 0.90
- Myeloid Commitment · correlation 0.88
- Lymphoid-Primed Progenitor · correlation 0.88
- Lymphoid Progenitor TFs · correlation 0.86
- Quiescent HSC State · correlation 0.84
- Naive B Cell · correlation 0.84
- Lymphoid Progenitor Commitment · correlation 0.82
- T/NK Cell Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.