DUSP6 — Dual specificity phosphatase 6
DUSP6 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUSP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glucocorticoid Response Inflammation | CCM2L, CFAP20, INAFM2, INHBB, MIER2, MYLIP, NUAK1, OAZ2 +6 more | View in SCUBA |
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A +23 more | |
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BCL11A, BTG2, DOCK1, MN1, NLRP1, PTPRE, SEPTIN9, STARD9 +2 more | |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | CDKN1A, CSRNP1, DUSP1, DUSP2, ELL2, EZR, FOS, ICAM1 +26 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | AQP9, BACH1, CCR1, DAPP1, FYB1, IFI16, JAK2 | View in SCUBA |
About the gene
| Synonyms | MKP-3, PYST1 |
|---|---|
| Chromosome | 12: 89347235-89352501 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.