SEPTIN9 — Septin 9
SEPTIN9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEPTIN9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Synapse Cytoskeleton Cytoskeletal | ARHGAP4, ARHGAP45, ATP2A3, CD48, DDOST, ICAM3, IL32, LAPTM5 +8 more | |
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BCL11A, BTG2, DOCK1, DUSP6, MN1, NLRP1, PTPRE, STARD9 +2 more | |
| Innate lymphoid cells | Septin Cytoskeleton Cytoskeleton & motility | ATP6V0C, C17orf49, CIAO2A, COX16, DARS1, DDOST, GET3, H2AC6 +18 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGDIA, ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1 +4 more | |
| Natural Killer cells | Interferon NK Activation Inflammation | CYRIB, IFITM1, KLRK1, NHERF1, PLAAT4, RNASEK, TLE5, UBE2V1 | View in SCUBA |
About the gene
| Synonyms | AF17q25, KIAA0991, MSF, MSF1, PNUTL4, SEPT9, SeptD1 |
|---|---|
| Chromosome | 17: 77280569-77500596 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division |
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.