DOCK1 — Dedicator of cytokinesis 1
DOCK1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, ERC1, MAP4 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BCL11A, BTG2, DUSP6, MN1, NLRP1, PTPRE, SEPTIN9, STARD9 +2 more | |
| Lymphatic endothelial | Focal Adhesion Migration migration & adhesion | BIRC6, CDC42BPA, EIF4G3, GNAQ, LPP, NF1, PAM, PTK2 +2 more | View in SCUBA |
About the gene
| Synonyms | ced5, DOCK180 |
|---|---|
| Chromosome | 10: 126905409-127452517 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Apoptosis, Phagocytosis |
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.