BTG2 — BTG anti-proliferation factor 2

BTG2 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BTG2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN, JUNB +7 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2, IER5 +6 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	CD69, EGR1, FOS, FOSB, IER2, JUNB, LEPROTL1, LITAF +5 more	View in SCUBA
Endothelial	Notch Arterial Identity Endothelial cell development	ADAMTS1, ARID5A, BTG1, CRIP1, DLL4, EFNA1, EFNB2, GADD45A +14 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, KLF10, LDLR +3 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3, FOS +15 more
Goblet cells	Immediate Early Gene chromatin regulation & transcription	DUSP1, EGR1, FOS, FOSB, IER2, JUN, JUNB, JUND	View in SCUBA
Hematopoietic progenitor cells	Multipotent Progenitor Identity Stemness	BCL11A, DOCK1, DUSP6, MN1, NLRP1, PTPRE, SEPTIN9, STARD9 +2 more
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3, EIF5 +8 more	View in SCUBA
Lymphatic endothelial	DNA Damage Response DNA/chromatin regulation	BRD2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, MAFB, NR4A1 +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4, DUSP1 +39 more	View in SCUBA
Monocytes	AP-1 Stress Response Stress	FOSB, MYLIP, PLK3, PMAIP1, PPP1R10, PPP1R15B, RGS2, VMP1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1, FOSB +7 more
Neutrophils	Immediate Early Response Stress	ADM, DUSP1, EGR1, FOS, IER2, JUNB, ZFP36
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, CDKN1A, EGR1, FOS, GADD45B, HES1, IER2 +7 more	View in SCUBA

About the gene

Synonyms	APRO1, MGC126063, MGC126064, PC3, TIS21
Chromosome	1: 203305491-203309602
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Transcription, Transcription regulation

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.