BCL11A — BAF chromatin remodeling complex subunit BCL11A
BCL11A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCL11A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R, ITPR1 +9 more | View in SCUBA |
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BTG2, DOCK1, DUSP6, MN1, NLRP1, PTPRE, SEPTIN9, STARD9 +2 more |
About the gene
| Synonyms | BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, SMARCM1, ZNF856 |
|---|---|
| Chromosome | 2: 60450520-60554467 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.