MRC1 — Mannose receptor C-type 1
MRC1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MRC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Treg regulation Immune regulation | BCAS3, CDK14, CEBPA, CLNK, CNIH1, COL9A2, CPA5, FCRL3 +8 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4 +10 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ADAP2, ARHGAP18, CD84, FRMD4B, GNPDA1, LIPA, MAF | View in SCUBA |
About the gene
| Synonyms | bA541I19.1, CD206, CLEC13D, CLEC13DL, MRC1L1 |
|---|---|
| Chromosome | 10: 17809348-17911164 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Plasma proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Endocytosis, Host-virus interaction |
Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.