ELN — Elastin
ELN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, FBLN2, FGF18, GUCY1A1 +5 more | View in SCUBA |
| Fibroblasts | Elastin-Fibronectin ECM ECM production | ABI3BP, DDAH2, FN1, LRIG3, S100A4, SERPINE2, SOD3, SSC5D | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, FLT4, KCNN3 +10 more | View in SCUBA |
| Smooth muscle cells | Actin Dynamics Housekeeping Housekeeping | C12orf75, CAPZA2, CFL1, ENY2, PPIA, PRDX1, PSMB1, RAB2A +3 more | View in SCUBA |
About the gene
| Synonyms | SVAS, WBS, WS |
|---|---|
| Chromosome | 7: 74027789-74069907 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.