Lymphangiogenesis ECM
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
FLT4/VEGFR3 is the primary receptor for VEGF-C/D and the canonical marker of lymphatic endothelium, essential for lymphangiogenesis. TBX1 is a T-box transcription factor involved in vascular and lymphatic development. ELN (elastin) is a major ECM component of vessel walls. TGFBR2 mediates TGF-β signaling critical for lymphatic valve and vessel remodeling. ELK3 is an ETS transcription factor regulating endothelial gene expression. MYH10 (non-muscle myosin IIB) drives cell shape changes during morphogenesis. EGFL7 is an endothelial-secreted ECM protein. MRC1 (CD206, mannose receptor) marks lymphatic endothelium in intestine. SLCO2B1 is an organic anion transporter expressed in endothelium. KCNN3 is a calcium-activated potassium channel. This module represents lymphatic vessel development with ECM remodeling, closely related to M36 (PROX1-driven identity) and M37 (pan-endothelial identity).
Genes
ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4, KCNN3, MAGED1, MAP4K2, MRC1, MYH10, REEP1, SLCO2B1, SMYD2, TBX1, TGFBR2, TSPAN18
Most correlated modules
- Lymphatic Valve Development · correlation 0.90
- Endothelial Identity · correlation 0.89
- Actin Cytoskeletal Scaffold · correlation 0.86
- Lymphatic Vascular Stability · correlation 0.84
- Anticoagulant Barrier · correlation 0.82
- Innate Immune Activation · correlation 0.76
- Endothelial Receptor Signaling · correlation 0.76
- Lymphatic Specification · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.