MRC2 — Mannose receptor C type 2
MRC2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MRC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-ECM Fibroblast ECM remodeling | ACVRL1, CLEC11A, GNG11, ITGB5, LAMA2, TFPI, VCAN | View in SCUBA |
About the gene
| Synonyms | CD280, CLEC13E, ENDO180, KIAA0709 |
|---|---|
| Chromosome | 17: 62627670-62693597 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Endocytosis |
Function
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.