TFPI — Tissue factor pathway inhibitor
TFPI belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFPI's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-ECM Fibroblast ECM remodeling | ACVRL1, CLEC11A, GNG11, ITGB5, LAMA2, MRC2, VCAN | View in SCUBA |
| Lymphatic endothelial | Anticoagulant Barrier endothelial development | AP2A2, ERICH1, JUP, KBTBD11, MMRN1, MYCT1, PARD6G, TIMP3 | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Lysosomal & pahgocytosis | AP2A2, BLVRB, CD163, FAH, FCGRT, HTRA1, MKKS, MYO7A +6 more | View in SCUBA |
About the gene
| Synonyms | EPI, LACI, TFI, TFPI1 |
|---|---|
| Chromosome | 2: 187464230-187565760 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
| Biological process | Blood coagulation, Hemostasis |
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.