GNG11 — G protein subunit gamma 11
GNG11 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNG11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Endothelial Identity Endothelial cell development | ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1 +14 more | View in SCUBA |
| Fibroblasts | BMP-ECM Fibroblast ECM remodeling | ACVRL1, CLEC11A, ITGB5, LAMA2, MRC2, TFPI, VCAN | View in SCUBA |
| Glial cells | Reactive Glial Activation Activation | ANP32B, ANTXR1, CTSD, FAM20C, MAP1B, PKM, PTEN, RASEF +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Platelet Biogenesis Myeloid development | CAVIN2, CCL5, CMTM5, F13A1, GP9, MAP3K7CL, NRGN, PF4 +6 more | |
| Lymphatic endothelial | Lymphatic EC Identity endothelial development | ATP6AP2, BEX3, CD151, FDPS, LMO2, MGST3, NAA38, POLR2L +2 more | View in SCUBA |
| Smooth muscle cells | Costameric cytoskeleton Cytoskeletal | ACTR2, AOC3, APLP2, CTDSPL, FLNC, HSPG2, KANK2, NFIA +4 more | View in SCUBA |
About the gene
| Synonyms | GNGT11 |
|---|---|
| Chromosome | 7: 93921735-93928610 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Transducer |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.