ITGB5 — Integrin subunit beta 5
ITGB5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGB5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Fibroblasts | BMP-ECM Fibroblast ECM remodeling | ACVRL1, CLEC11A, GNG11, LAMA2, MRC2, TFPI, VCAN | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | DAB2, ETV5, FOLR2, FRMD4A, GPNMB, LGMN, LILRB5, LYVE1 +7 more | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more | View in SCUBA |
About the gene
| Chromosome | 3: 124761948-124901418 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Integrin, Receptor |
| Biological process | Cell adhesion, Host-virus interaction |
Function
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.