MROH1 — Maestro heat like repeat family member 1
MROH1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MROH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
About the gene
| Synonyms | HEATR7A, KIAA1833 |
|---|---|
| Chromosome | 8: 144148016-144261927 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Lysosome fission factor. Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.