MSR1 — Macrophage scavenger receptor 1
MSR1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MSR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Monocytes | Macrophage Differentiation Developmental | C7orf50, CABP4, FCGR3B, FMNL2, IL3RA, MS4A4A, PPM1N, PPP1R17 +3 more | View in SCUBA |
About the gene
| Synonyms | CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII |
|---|---|
| Chromosome | 8: 16107878-16567490 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Endocytosis |
Function
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.