Alternative Activation Lipid
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 33 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 33 genes have a known function matching the annotation |
Why this annotation
ACSL1 (long-chain fatty acid-CoA ligase, key enzyme in fatty acid metabolism and lipid droplet formation) and SGMS2 (sphingomyelin synthase 2, sphingolipid metabolism) are top metabolic hubs. GPD2 (mitochondrial glycerophosphate dehydrogenase) links glycolysis to lipid metabolism. BCL6 and ARID5B are transcription factors associated with macrophage alternative/anti-inflammatory activation (M2 polarization). COLEC12 is a scavenger receptor involved in lipid and apoptotic cell uptake. CD55 (complement decay-accelerating factor) protects cells from complement. PANX1 and CLIC4 are ion channels involved in macrophage signaling. SLC16A10 (aromatic amino acid transporter) and SLC1A3 (glutamate transporter) add metabolic transport context. The lipid metabolism genes combined with M2-associated transcription factors suggest alternatively activated macrophage lipid handling.
Genes
ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13, CD55, CLIC4, CLIP4, COLEC12, DENND5A, FAM20A, FGD5, GPD2, GPR137B, KCNE1, LONRF1, MINK1, MSR1, MYO1E, PANX1, PLPP3, RASAL2, RIPK2, RUNX1, SGMS2, SLC16A10, SLC1A3, SLC39A11, SLC41A2, TNS1
Most correlated modules
- RAB-mediated Trafficking · correlation 0.92
- Hypoxia-driven Activation · correlation 0.90
- Monocyte-Mac Iron Transport · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.