AGFG1 — ArfGAP with FG repeats 1
AGFG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGFG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, CCND3, CD164, CHMP2B, DBF4, GHITM, HNRNPL, LSM1 +9 more | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13, CD55 +24 more | View in SCUBA |
| Monocytes | Autophagy Initiation Lysosomal & pahgocytosis | AAK1, ARID3B, FHIP2A, PHC2, PTK2B, RIOK3, TMCO3, TRABD +1 more | View in SCUBA |
About the gene
| Synonyms | HRB, RAB, RIP |
|---|---|
| Chromosome | 2: 227472152-227561217 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein, DNA-binding |
| Biological process | Differentiation, mRNA transport, Spermatogenesis, Transport |
Function
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.