ATP2B4 — ATPase plasma membrane Ca2+ transporting 4
ATP2B4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP2B4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1, ITGA4 +8 more | View in SCUBA |
| Endothelial | WAVE Complex Cytoskeleton Cytoskeletal | C6orf89, CD46, CYFIP1, DYNC1LI2, GIT1, GNB1, IQGAP1, MAP7D1 +3 more | View in SCUBA |
| Fibroblasts | Rho-ROCK Contractility Cytoskeletal | ANXA6, CBX6, CSDE1, DYNLT3, GNG12, ITM2C, PPP1CB, ROCK1 +1 more | View in SCUBA |
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ADCY7, CYFIP2, DIAPH1, GK5, GLG1, ITGAL, NBEAL2, NFATC3 +4 more | |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, BCL6, CCL13, CD55 +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4, OGDH +8 more | |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2, JAK1 +13 more | View in SCUBA |
About the gene
| Synonyms | ATP2B2, MXRA1, PMCA4 |
|---|---|
| Chromosome | 1: 203626832-203744081 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Calmodulin-binding, Translocase |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.