ADCY3 — Adenylate cyclase 3

ADCY3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ADCY3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Th1 IL12 response Immune regulation	AKIRIN2, CTNNA1, ETV7, HIVEP3, IL12RB2, JAKMIP1, PTPN1, RFTN1 +2 more	View in SCUBA
Gamma-delta T cells	Basal Lipid Metabolism Housekeeping	ACOT7, AHCY, CLN6, DENND6B, FANCL, MGLL, MPST, NUDT8 +6 more
Macrophages	Alternative Activation Lipid Lipid metabolism	ACSL1, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13, CD55 +24 more	View in SCUBA
Pericytes	Pericyte Identity Signaling Developmental	CCDC102B, FBLIM1, NOTCH3, OLFML2B, PDGFRB, PEAK1, PLXDC1	View in SCUBA
Smooth muscle cells	Vascular Tone Signaling Contractility	CPEB4, CYSTM1, DBI, EPAS1, EPS8, IER5L, NR2F2, PDE3A +5 more	View in SCUBA

About the gene

Synonyms	AC3
Chromosome	2: 24819169-24920237
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Calmodulin-binding, Lyase
Biological process	cAMP biosynthesis, Olfaction, Sensory transduction

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.