ACSL1 — Acyl-CoA synthetase long chain family member 1
ACSL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Alternative Activation Lipid Lipid metabolism | ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13, CD55 +24 more | View in SCUBA |
| Monocytes | NLRP3 Inflammasome Activation Innate immunity | BASP1, CCDC71L, CCL20, EREG, F3, FAM107B, LRG1, NLRP3 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Tissue residence | AMFR, CRACDL, DHX36, HES4, IRF8, ITGAE, LZTFL1, MACO1 +8 more | |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5, PTPN12 +6 more |
About the gene
| Synonyms | ACS1, FACL1, FACL2, LACS, LACS1, LACS2 |
|---|---|
| Chromosome | 4: 184755595-184826818 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.