NECTIN4 — Nectin cell adhesion molecule 4
NECTIN4 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NECTIN4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Inflammatory Stress Response Stress | ANXA3, ANXA5, BCAP29, C4orf3, CD47, CKLF, DNTTIP1, FERMT1 +13 more | View in SCUBA |
About the gene
| Synonyms | LNIR, nectin-4, PRR4, PVRL4 |
|---|---|
| Chromosome | 1: 161070998-161089558 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Cell adhesion, Host-virus interaction |
Function
Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.