NEFL — Neurofilament light chain
NEFL belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NEFL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, BACH2, CCR7, CSGALNACT1, FHIT, FOXP1, LEF1 +6 more |
About the gene
| Synonyms | CMT1F, CMT2E, NF68, NFL, PPP1R110 |
|---|---|
| Chromosome | 8: 24950955-24956721 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.