Naive T cell
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Core hub genes LEF1, CCR7, SELL (CD62L), FOXP1, BACH2, MAL, and ARID5B are canonical markers of naive and central memory T cell identity. CCR7 and SELL drive lymph node homing; LEF1, BACH2, and FOXP1 are transcription factors maintaining naive T cell fate. SERINC5 and AK5 are also enriched in naive T cells. Core coherence and uniform low expression are consistent with a naive MAIT subpopulation state.
Genes
AK5, ARID5B, BACH2, CCR7, CSGALNACT1, FHIT, FOXP1, LEF1, MAL, NEFL, SELL, SERINC5, TESPA1, TRABD2A, TSHZ2
Most correlated modules
- NK-like Cytotoxic · correlation 0.76
- Chromatin Remodeling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.