CSGALNACT1 — Chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSGALNACT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANK3, ANTXR2, CD24, COL4A3, COL4A4, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| CD4⁺ T cells | Naive T quiescence T cell development | CCR7, CD55, CRIP2, ITGA6, KLF2, KLF3, NOSIP, RASA3 +6 more | View in SCUBA |
| Lymphatic endothelial | Lipid Metabolic Regulation Lipid metabolism | ANKS1A, DYSF, EFNA5, KALRN, LDB2, MLLT10, PLD1, PPARG +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, BACH2, CCR7, FHIT, FOXP1, LEF1, MAL +6 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, FLI1, IQGAP2, LYST, PDZD8, PHIP +5 more |
About the gene
| Synonyms | ChGn, CSGalNAcT-1, FLJ11264 |
|---|---|
| Chromosome | 8: 19404161-19758029 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.