LEF1 — Lymphoid enhancer binding factor 1
LEF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LEF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| CD8⁺ T cells | Naive/Central Memory T cell maturation | AIF1, ATM, CCR7, FCMR, FOXP1, KLF2, KLF3, LDLRAP1 +7 more | View in SCUBA |
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, MTHFD2, NEURL1B +5 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GJA1, GNG2, MFGE8, PAPLN +5 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, DPYD +7 more | |
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, BACH2, CCR7, CSGALNACT1, FHIT, FOXP1, MAL +6 more |
About the gene
| Synonyms | TCF10, TCF1ALPHA, TCF7L3 |
|---|---|
| Chromosome | 4: 108047545-108168956 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.