NEURL3 — Neuralized E3 ubiquitin protein ligase 3
NEURL3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NEURL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Type I Interferon Inflammation | ACP2, BIRC3, CMPK2, DENND3, EPSTI1, HDAC9, HELZ2, HERC6 +16 more | View in SCUBA |
About the gene
| Synonyms | Lincr, LOC93082, RNF132 |
|---|---|
| Chromosome | 2: 96497646-96508109 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7. Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2. Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.