CMPK2 — Cytidine/uridine monophosphate kinase 2
CMPK2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMPK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Antiviral ISG Response Inflammation | HELZ2, HERC5, IFIT1, IFIT3, ISG20, MX2, NT5C3A, PPM1K +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IFIT5 +9 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1, IFIT2 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Antiviral | DEFB1, HERC5, IFIT1, IFIT2, IFIT3, OASL, OPTN, RSAD2 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | HELZ2, HERC6, IFIT1, LAMP3, LGALS9, MX2, OAS3, PLSCR1 +2 more |
About the gene
| Synonyms | NDK, TYKi, UMP-CMPK2 |
|---|---|
| Chromosome | 2: 6840570-6866635 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Pyrimidine biosynthesis |
Function
Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.