HDAC9 — Histone deacetylase 9
HDAC9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HDAC9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Treg regulation Immune regulation | BCAS3, CDK14, CEBPA, CLNK, CNIH1, COL9A2, CPA5, FCRL3 +8 more | View in SCUBA |
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Hematopoietic progenitor cells | Dendritic Cell Progenitor Myeloid development | BLNK, CCDC50, CD180, CLEC4A, HERPUD1, IRF8, LY86, NCF1 +1 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | ALDH1A1, CPED1, DAAM2, EIF4B, FN1, H2AC19, IGHA2, LPL +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | CHST11, MGAT5, NCAM1, NCOA2, PITPNC1, RASA2, SSH2 |
About the gene
| Synonyms | HD7, HDAC, HDAC7B, KIAA0744, MITR |
|---|---|
| Chromosome | 7: 18086949-19002416 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Hydrolase, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.