EPSTI1 — Epithelial stromal interaction 1

EPSTI1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EPSTI1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	MAPK feedback signaling TCR/AP1/NFKb pathway	BACH1, DUSP16, DUSP4, E2F3, MAT2B, PELI1, PIM2, SEC14L1 +2 more	View in SCUBA
CD8⁺ T cells	Type I Interferon Inflammation	IFI35, IFI44, IFI44L, IFI6, IRF7, ISG15, LGALS9, MX1 +3 more	View in SCUBA
Endothelial	IFN-gamma Response Inflammation	APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more	View in SCUBA
Fibroblasts	Immunoproteasome MHC-I Inflammatory	B2M, BST2, HLA-A, HLA-B, HLA-C, HLA-F, IFI27, PPA1 +7 more	View in SCUBA
Gamma-delta T cells	Interferon Stimulated Response Inflammation	AK3, AP2A1, CTNNBL1, CYB5R3, DRG2, EXOSC8, GPANK1, GUSB +6 more
Macrophages	Immunoproteasome Induction Inflammatory	CBR1, DAPP1, DYNLT1, IFI35, LAP3, LGALS9, LYSMD2, NADK +12 more	View in SCUBA
Monocytes	Type I Interferon Response Antiviral	IFI44, IFI44L, IFI6, IRF7, MX1, OAS2, OAS3, PARP12 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Type I Interferon Inflammation	DDX60, DDX60L, DTX3L, EIF2AK2, GBP2, GBP4, HERC5, IFI16 +18 more

About the gene

Synonyms	BRESI1, MGC29634
Chromosome	13: 42886388-42992271
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins

Function

Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.