HELZ2 — Helicase with zinc finger 2
HELZ2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HELZ2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Antiviral ISG Response Inflammation | CMPK2, HERC5, IFIT1, IFIT3, ISG20, MX2, NT5C3A, PPM1K +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IFIT5 +9 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | ABHD5, ICAM4, IQCN, IRF7, IRF8, IRF9, LACTB, MYLIP +2 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, IFI27, IFI44, IFI44L, IFI6, IFIT1, IFIT2 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HERC6, IFIT1, LAMP3, LGALS9, MX2, OAS3, PLSCR1 +2 more |
About the gene
| Synonyms | KIAA1769, PDIP1, PRIC285 |
|---|---|
| Chromosome | 20: 63558086-63574239 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Exonuclease, Helicase, Hydrolase, Nuclease, RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Can degrade highly structured RNAs through its concerted ATP- dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.