DENND3 — DENN domain containing 3
DENND3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, EVL, IDH2, IL17RE, IL23R +13 more | View in SCUBA |
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1, PHLPP1 +8 more | View in SCUBA |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, EIF4B +31 more | View in SCUBA |
| Natural Killer cells | NK Cell Exhaustion Immune regulation | CEBPB, CEMIP2, FMNL1, HAVCR2, IFNGR1, METRNL, PDE4D, PRNP +3 more | View in SCUBA |
About the gene
| Synonyms | KIAA0870 |
|---|---|
| Chromosome | 8: 141117278-141195808 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4. Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.