NSF — N-ethylmaleimide sensitive factor, vesicle fusing ATPase
NSF belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | ADGRG5, AGAP1, BCL2, CDK6, JAKMIP2, PARP15, PIK3R5, PTPN4 +9 more |
About the gene
| Synonyms | SEC18, SKD2 |
|---|---|
| Chromosome | 17: 46590669-46757679 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Hydrolase |
| Biological process | Protein transport, Transport |
Function
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.