PIK3R5 — Phosphoinositide-3-kinase regulatory subunit 5
PIK3R5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIK3R5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PLXNC1, PREX1 +6 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | APMAP, C16orf54, CST7, CTSW, EHD1, HLA-A, HLA-B, HLA-C +8 more | |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
| Monocytes | Endosomal Sorting Vesicular traficking | FPGS, GAB2, GGA2, HGS, MAFG, SEMA6B, SSH1, TPRA1 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | ADGRG5, AGAP1, BCL2, CDK6, JAKMIP2, NSF, PARP15, PTPN4 +9 more | |
| Natural Killer cells | NK Cell Identity Differentiation | APBA2, APMAP, COLQ, ETS1, FCMR, FKBP11, GSAP, ICAM2 +2 more | View in SCUBA |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PTPN12 +6 more |
About the gene
| Synonyms | p101, P101-PI3K |
|---|---|
| Chromosome | 17: 8878911-8965712 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
Function
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.