BCL2 — BCL2 apoptosis regulator
BCL2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ACAP1, ARHGAP15, CD44, CD46, DSE, EML4, FCGR2B, GATAD1 +7 more | View in SCUBA |
| CD4⁺ T cells | Membrane trafficking Housekeeping | CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP, MCF2L2 +19 more | View in SCUBA |
| Gamma-delta T cells | T Cell Migration migration & adhesion | BPNT2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3, MDFIC +14 more | |
| Macrophages | RNA Processing Transport Housekeeping | CDYL, CPSF6, DHX15, DHX9, EFR3A, EXOC1, FBXO38, GLYR1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | ADGRG5, AGAP1, CDK6, JAKMIP2, NSF, PARP15, PIK3R5, PTPN4 +9 more |
About the gene
| Synonyms | Bcl-2, PPP1R50 |
|---|---|
| Chromosome | 18: 63123346-63320128 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Autophagy |
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1- inflammasome activation, hence CASP1 activation and IL1B release.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.