AGAP1 — ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGAP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte differentiation TFs Chromatin regulation & transcription | ATXN1, DENND1B, DOCK5, GOLIM4, GRAMD2B, HNF4G, JMJD1C, LCORL +7 more | View in SCUBA |
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM, MYO1G +7 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | ADGRG5, BCL2, CDK6, JAKMIP2, NSF, PARP15, PIK3R5, PTPN4 +9 more |
About the gene
| Synonyms | CENTG2, GGAP1, KIAA1099 |
|---|---|
| Chromosome | 2: 235494043-236131793 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
| Biological process | Protein transport, Transport |
Function
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)- dependent trafficking of proteins in the endosomal-lysosomal system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.