ADGRG5 — Adhesion G protein-coupled receptor G5
ADGRG5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRG5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation BCR/AP1/NFKb pathway | BCAR3, CD86, CLIP2, CNOT2, CTSH, FAS, GABARAPL2, GPR137B +7 more | View in SCUBA |
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT, MATK +11 more | |
| Hematopoietic progenitor cells | Lymphocyte Signaling Lymphcyte development | AHR, AKNA, CARD11, CORO1A, CYTH4, KIAA0930, LSP1, PAK1 +3 more | |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, AIG1, AXL, CCS, CD101, CD1D, CD300A, EVA1B +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGAP1, BCL2, CDK6, JAKMIP2, NSF, PARP15, PIK3R5, PTPN4 +9 more |
About the gene
| Synonyms | GPR114, PGR27 |
|---|---|
| Chromosome | 16: 57542643-57591681 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Orphan adhesion G-protein coupled receptor (aGPCR). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG5 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.