Cytoskeletal Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
RIPOR2 (FAM65B) is a RhoA inhibitor critical for lymphocyte polarity, adhesion, and migration — it restrains integrin-mediated arrest. SVIL (supervillin) is an actin-binding protein at the plasma membrane regulating cytoskeletal organization. VCL (vinculin) is a focal adhesion protein linking integrins to actin. PTPRC (CD45) is the major phosphatase regulating lymphocyte receptor signaling. PIK3R5 encodes p101, the regulatory subunit of PI3Kγ, a GPCR-coupled PI3K isoform driving chemokine-mediated lymphocyte migration. RAP1GAP2 inactivates RAP1, which controls integrin affinity. NSF mediates vesicle fusion. ADGRG5 is an adhesion GPCR. BCL2 promotes survival. CDK6 is a cell cycle kinase. The dominant theme is actin cytoskeleton-dependent migration and adhesion regulation in lymphocytes, with RIPOR2 and SVIL as the strongest anchors.
Genes
ADGRG5, AGAP1, BCL2, CDK6, JAKMIP2, NSF, PARP15, PIK3R5, PTPN4, PTPRC, RAP1GAP2, RIPOR2, SRPK2, ST6GAL1, STK38, SVIL, TC2N, VCL
Most correlated modules
- Lymphocyte Migration · correlation 0.88
- Chromatin Remodeling · correlation 0.83
- Calcineurin-NFAT Signaling · correlation 0.83
- Immune Synapse Signaling · correlation 0.75
- RAS-GEF Signaling · correlation 0.73
- Cytoskeletal Migration · correlation 0.71
- NF-κB Immune Survival · correlation 0.71
- T cell Homeostasis · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.