PDE7B — Phosphodiesterase 7B
PDE7B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE7B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more | View in SCUBA |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, DIAPH2, EBF1, HIP1, PDE4D, PELI2, PLCB4 | View in SCUBA |
About the gene
| Chromosome | 6: 135851701-136195574 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.