PELI2 — Pellino E3 ubiquitin protein ligase family member 2
PELI2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PELI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell signaling T cell development | AFF3, RASGRF2, RNF130, TESPA1, TRIM44, ZFYVE9, ZNF506 | View in SCUBA |
| Endothelial | NF-κB Stress Signaling Inflammation | AKR1C3, ELK4, EPS15, METRNL, MYCBP2, NFAT5, PALM, PGM5 +4 more | View in SCUBA |
| Enterocytes | Junctional Hippo/TGF-beta signaling Migration & adhesion | AFDN, BACH1, CCNL1, DAPK2, DST, SMAD3, UACA, WWC1 | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2 +19 more | |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, DIAPH2, EBF1, HIP1, PDE4D, PDE7B, PLCB4 | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, MXI1, NR3C1, PROSER1, RB1CC1, RCOR1, RFTN1 +7 more | |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ACAP2, ARHGAP15, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L +9 more |
About the gene
| Chromosome | 14: 56117814-56301524 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3- dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.