Inflammatory cAMP Response
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
DIAPH2 (formin, actin polymerization), ARL15 (Arf-like GTPase, insulin/lipid signaling), PDE4D and PDE7B (cAMP phosphodiesterases), PLCB4 (PLC-beta4, downstream of Gq/GNAQ — linking to M66), and EBF1 (transcription factor with roles in lymphatic valve specification and B-cell development) form this module. The significant delta_inflammation_CD (2.432, sig.) suggests inflammation-responsive upregulation. PDE4D is a well-known anti-inflammatory cAMP regulator. EBF1 is expressed in LECs and regulates lymphatic identity. PELI2 is an E3 ligase in inflammatory NF-kB signaling. The combination of cAMP signaling, formin-mediated cytoskeletal remodeling, and EBF1 in an inflammation-responsive context suggests an LEC-intrinsic inflammatory cytoskeletal response program.
Genes
ARL15, DIAPH2, EBF1, HIP1, PDE4D, PDE7B, PELI2, PLCB4
Most correlated modules
- Cilia Centrosome Program · correlation 0.95
- Polarized Vesicle Trafficking · correlation 0.95
- Actin-based Migration · correlation 0.95
- Focal Adhesion Migration · correlation 0.95
- Hippo-Adhesion Signaling · correlation 0.94
- Rho/Ras GTPase Regulation · correlation 0.93
- Chromatin Remodeling · correlation 0.92
- Lipid Metabolic Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.