DIAPH2 — Diaphanous related formin 2
DIAPH2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DIAPH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ATL3, ECE1, EID1, GOLIM4, KTN1, MAGT1, PGK1, SHISA5 +4 more | View in SCUBA |
| Enterocytes | Crypt antimicrobial progenitor Antibacterial | CAMK1D, CHRM3, EMP2, HES1, IFITM2, LYZ, PTPN13, SULF2 | View in SCUBA |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, EBF1, HIP1, PDE4D, PDE7B, PELI2, PLCB4 | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
About the gene
| Synonyms | DIA, DIA2, POF, POF2 |
|---|---|
| Chromosome | X: 96684712-97604997 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Oogenesis |
Function
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.