PGLYRP1 — Peptidoglycan recognition protein 1
PGLYRP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGLYRP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Secondary Granule Antibacterial Degranulation | CAMP, CHI3L1, CHIT1, CRISP3, CYBB, HP, LCN2, LTF +3 more |
About the gene
| Synonyms | PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L |
|---|---|
| Chromosome | 19: 46019153-46023053 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial |
| Biological process | Immunity, Innate immunity |
Function
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram- positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.