PHF21A — PHD finger protein 21A
PHF21A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF21A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Granulopoiesis Transcriptional Developmental | EXT1, KLHL2, MAML3, PDE3B, SIPA1L2, STAT5B, TPST1 |
About the gene
| Synonyms | BHC80, BM-006, KIAA1696 |
|---|---|
| Chromosome | 11: 45929319-46121454 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.