Granulopoiesis Transcriptional
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
STAT5B is a key JAK-STAT transcription factor activated downstream of G-CSF/GM-CSF during neutrophil maturation. MAML3 is a Notch transcriptional co-activator implicated in granulopoiesis. PHF21A is a chromatin regulator (KDM1A complex) controlling gene expression during differentiation. PDE3B degrades cAMP to modulate maturation signals. SIPA1L2 is a Rap1 GAP regulating integrin signaling during differentiation. TPST1 performs tyrosine sulfation of surface receptors. EXT1 synthesizes heparan sulfate proteoglycans important for cytokine presentation. KLHL2 is a ubiquitin adaptor regulating protein stability. The module reflects a transcriptional/epigenetic regulatory program associated with neutrophil differentiation and maturation.
Genes
EXT1, KLHL2, MAML3, PDE3B, PHF21A, SIPA1L2, STAT5B, TPST1
Most correlated modules
- Endosomal Vesicle Trafficking · correlation 0.98
- Endocytic Vesicle Trafficking · correlation 0.98
- ER Stress Response · correlation 0.97
- PI3K Migration Signaling · correlation 0.97
- Stress Kinase Signaling · correlation 0.94
- Mature Neutrophil Identity · correlation 0.94
- TLR5 Bacterial Sensing · correlation 0.94
- Ubiquitin-Proteasome Turnover · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.