MAML3 — Mastermind like transcriptional coactivator 3
MAML3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAML3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte identity TFs Epithelial development | CAMK2G, MALRD1, PBX1, PLXDC2, SPTLC3, TPD52, TTC17, ZBTB20 | View in SCUBA |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, EPAS1, HIP1, LPIN1, MDFIC, RGS1, RHOQ +2 more | View in SCUBA |
| Neutrophils | Granulopoiesis Transcriptional Developmental | EXT1, KLHL2, PDE3B, PHF21A, SIPA1L2, STAT5B, TPST1 |
About the gene
| Synonyms | CAGH3, GDN, KIAA1816, MAM2, TNRC3 |
|---|---|
| Chromosome | 4: 139716753-140154184 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.