KLHL2 — Kelch like family member 2
KLHL2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLHL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Regulatory T cell Immune regulation | ACTA2, APOLD1, ATP13A3, CARD16, CD27, CD79B, DNAH8, FAM184A +7 more | View in SCUBA |
| Neutrophils | Granulopoiesis Transcriptional Developmental | EXT1, MAML3, PDE3B, PHF21A, SIPA1L2, STAT5B, TPST1 |
About the gene
| Synonyms | MAV |
|---|---|
| Chromosome | 4: 165207561-165323156 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Molecular function | Actin-binding |
| Biological process | Ubl conjugation pathway |
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation. The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.