PLEKHG2 — Pleckstrin homology and RhoGEF domain containing G2
PLEKHG2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEKHG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | PD-L1 checkpoint Immune regulation | ADAM12, CASS4, CCDC88B, CD274, GALNT10, HUWE1, INPP5D, KIF3B +13 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more | View in SCUBA |
About the gene
| Synonyms | ARHGEF42, CLG, FLJ00018 |
|---|---|
| Chromosome | 19: 39412669-39428415 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). Involved in the regulation of actin polymerization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.