POGZ — Pogo transposable element derived with ZNF domain
POGZ belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POGZ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
About the gene
| Synonyms | KIAA0461, ZNF280E, ZNF635 |
|---|---|
| Chromosome | 1: 151402724-151459494 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair |
Function
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Promotes the repair of DNA double-strand breaks through the homologous recombination pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.