POLE2 — DNA polymerase epsilon 2, accessory subunit
POLE2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | CENPU, DNAJC9, EIF2AK1, HLTF, MRPL52, PIP4K2A, SLC12A6, TLN1 +2 more |
About the gene
| Synonyms | DPE2 |
|---|---|
| Chromosome | 14: 49643555-49688422 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA replication |
Function
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.