DNAJC9 — DnaJ heat shock protein family (Hsp40) member C9
DNAJC9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDCA5, CDT1, CENPK, CENPU, CLSPN, FAM111B +5 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DSCC1, EBP, NCAPH2, PCLAF, RRM1 +5 more | View in SCUBA |
| Endothelial | S-phase DNA Replication Cell cycle | CHEK1, FANCA, HELLS, LIG1, MCM7, PCNA, RFC4, WDR76 | View in SCUBA |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CENPM, CLSPN, FANCI, LIG1, PKMYT1, RRM1 | View in SCUBA |
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | CENPU, EIF2AK1, HLTF, MRPL52, PIP4K2A, POLE2, SLC12A6, TLN1 +2 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | JDD1, SB73 |
|---|---|
| Chromosome | 10: 73183362-73247255 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Acts as a dual histone chaperone and heat shock co-chaperone. As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes. May also act as a histone co-chaperone together with TONSL. May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers. Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8. As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity. Exhibits activity to assemble histones onto DNA in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.